Coronary Thrombosis in a Patient with COVID-19 Who Was on Anticoagulant Therapy

Introduction: COVID-19-related thrombotic events are associated with an increase in the risk of mortality and morbidity. Considering the research on the pathophysiology of the disease, the significance of cardiac thrombosis is being more recognized. Case Presentation: This study aimed to present the first case report of a Left Main Coronary Artery (LMCA) thrombosis due to COVID-19 infection in a middle-aged male with a mechanical valve on anticoagulant therapy and with an International Normalized Ratio (INR) within the therapeutic range. Conclusions: The results suggested that the therapeutic INR range may need to be higher (about 3.5) during the acute phase of COVID-19 infection to prevent thrombotic events amongst patients with COVID-19 who are on anticoagulant therapy. However, further evidence is required to determine the target range for INR in patients with COVID-19 who are on anticoagulants prior to infection.

Knowledge, attitude, and practice toward covid-19 among healthcare workers in Shiraz, Iran

Background: The coronavirus disease 2019 (COVID-19) pandemic is a critical world concern, with healthcare workers (HCWs) at a high risk of infection. Thus, a sufficient level of knowledge, attitude, and practice (KAP) must be ensured. Objectives: We aimed to investigate the KAP toward COVID-19 among HCWs in Shiraz, Iran. Methods: A cross-sectional study was performed on a large sample of HCWs dealing with the COVID-19 pandemic in multiple hospitals affiliated to the Shiraz University of Medical Sciences. The survey featured four sections: demographic data, knowledge, attitude, and practice. An expert panel validated the questionnaire, and its reliability was ensured through a pilot study on 20 HCWs (Cronbach’s alpha = 0.9). Results: We found that 72.8% of HCWs had sufficient knowledge, 66.65% indicated correct attitudes, and 67.72% described good practices. However, 24.23% thought adequate protective equipment or facilities are unavailable. The knowledge scores were lowest on prevention and diagnosis, though symptoms were well-recognized. The male gender was correlated with more correct attitudes. Among nurses, 2-5 years of work experience was associated with better practice, with a master’s degree being related to more positive attitudes. Conclusions: The KAP of HCWs toward COVID-19 are acceptable in Shiraz, but further education and training is beneficial, especially on disinfectants and prevention;reassurance regarding protective equipment is also vital. © 2020, Author(s).